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Intranasal BBB bypass is a validated human pharmacological route actively used for other biologics (e.g., intranasal oxytocin and insulin)

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The practical takeaway: Injection = high systemic distribution → tendons, ligaments, muscle, joints, vascular tissue Oral = high local GI concentration → intestinal lining, gastric mucosa, gut repair Nasal = intermediate systemic delivery → potential neurological targeting, emerging evidence only Injectable BPC-157: Highest Bioavailability for Systemic and Musculoskeletal Goals Injectable BPC-157 is the best-studied delivery method for healing applications outside the gastrointestinal tract