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In insulin-responsive tissues, the equilibrium between MI and its epimer D-chiro-inositol (DCI) is important because insulin promotes the epimerase-mediated conversion of MI into DCI, which is then incorporated into GPI-anchored proteins and released as DCI-IPGs following insulin stimulation (137)

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Other studies have shown that ROS production in response to glutamine deprivation increases the expression of p53-dependent genes ( Gadd45a, Cdkn1, and Sestrin2 ) via B55α or IKKβ 124,125