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DSIP should be approached with particular caution by individuals with severe psychiatric conditions, untreated sleep disorders like severe sleep apnea, or those taking medications affecting the central nervous system

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The peptide was originally believed to be involved in sleep regulation because it appeared to induce slow-wave sleep in rabbits, but as that same source notes, "studies on the subject have been contradictory." DSIP has low molecular stability in vitro, with a half-life reported at about 15 minutes, attributed to a specific aminopeptidase-like enzyme