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There has been some support for the idea that Bcl-2 along with the 2-oxoglutarate carrier function as GSH transporters, based on correlations between Bcl-2 expression and nuclear GSH levels in cancer, however, this idea has been abandoned since the 2-oxoglutarate carrier has been refuted as a GSH transporter [76,78]

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It has been shown that compromise of Nrf2 function can occur due to modification of Nrf2 after production, even when its production is upregulated [45]