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In a smaller, double-blind, placebo-controlled trial in 256 older adults, ages 60-75 years, co-supplementation with 300 mg/day of all - rac -α-tocopherol and 400 mg/day of vitamin C for one year reduced a biomarker of oxidative stress (malondialdehyde) but had no effect on cognitive performance — measured by the Mini Mental State Examination (MMSE) scoring system (109)