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While kojic acid is generally well-tolerated, there are some important safety points to keep in mind

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First, a nodule is not automatically benign: the FDA has flagged that parenteral BPC-157 carries risks of immunogenicity, reactivity from peptide-related impurities and aggregate formation , which is why the agency placed it in Category 2 of the section 503A bulk drug substances list, and an injection-site reaction can be the first visible sign of any of those