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While it is known that B-vitamin supplementation effectively treats hyperhomocysteinemia, there is a need for well-designed, large trials to evaluate the effect of B-vitamin supplementation on long-term outcomes, such as age-related cognitive decline and the incidence of Alzheimer’s disease

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A hydrogen bond between Lys59 in LET7 TPR and Gln440 in LET7 PPase stabilizes the intramolecular interaction of LET7 (Fig