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There are constant interactions with the NO system and capsaicin-sensitive somatosensory neurons, since it consistently appears in naive rats as well as in those challenged with NOS blockade (NOS blocker L-NAME), NOS substrate L-arginine (NOS over-activity), NO system immobilization (concomitant application of L-NAME and L-arginine), capsaicin (as newborn or adult), or small exogenous or endogenous irritants[1,7]