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In order to confirm the role of CD36 to palmitate-induced ferroptosis, we silenced CD36 in SUM-159 cells by using two pooled siRNAs and showed a decrease of CD36 expression even in presence of PA at RNA and protein levels (Fig
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Emerging human data, including small pilot studies showing good tolerability (e.g., intravenous infusions up to 20 mg with no adverse effects) and subjective improvements in conditions like chronic knee pain, further support its promise
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