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Nevertheless, these methodologies are associated with a high risk of infections, inflammation, high intracranial pressure, and damage to the brain tissue, and most of them are not suitable for chronic treatments [8,11]

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3.3 Changes in serum cobalamin by supplementation route and dosage Across 35 comparisons, the mean percentage increase in serum cobalamin following supplementation was approximately 293%, confirming the overall effectiveness of vitamin B12 interventions (Supplementary Table S4)