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The non-overlapping mechanism question The case for stacking, on paper: Cagrilintide targets the amylin receptor Retatrutide targets GLP-1, GIP, and glucagon receptors None of these receptors overlap Each adds independent appetite-suppressive and metabolic effects Therefore the combined effect should be additive or synergistic The case for not stacking, on paper: Non-overlapping receptors do not guarantee non-overlapping downstream signaling