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This promotes Nrf2 nuclear translocation and ARE binding, upregulating antioxidant enzymes such as Superoxide Dismutase 1(SOD1), Heme Oxygenase-1(HO-1), and Glutathione Peroxidase (GPx) ( In summary, curcumin orchestrates a multi-dimensional anti-photoaging network through Keap1-Nrf2 pathway regulation, integrating antioxidant defense (low doses), cell cycle intervention (moderate doses), and pro-apoptotic effects (high doses)

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Aging is one of the most important risk factors of AD [39]