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the second is to prepare the drug into liquid and then carry out aseptic split charging directly, then carry on freeze drying, its advantage is that the difference of the charge is easy to control, can strengthen the stability of the drug, the disadvantage is for reduced glutathione, the condition of freeze drying is not easy to control, cause the rejection rate to be higher, even influence the stability of the drug in the valid period

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If a compound or molecule has low pK (less than 2.5), it has low affinity for binding protons

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