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Subcutaneous protocols achieve peak plasma levels within 2–4 hours and maintain therapeutic concentrations for 12–16 hours, which supports once-daily dosing
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Sjögren's syndrome definition was developed by the team of experts from Europe and America, "European American consensus group criteria" (EACG) that requires for recognition criteria: Subcjective ocular symtoms: symptoms of dry eyes over 3 months, forgein body sensation in the eyes, Subjective oral symtoms: symtoms of dry mouth over 3 months, swollen salivary glands Objcective ocular signs: Abnormal Schirmer Test ( tears flow less then 5 mm in 5 minutes) Objective oral signs: unstimulated whole salivary flow less then 1.5 ml in 15 minutes, abnormal parotid sialography, abnormal salivary scintigraphy Positive histopathological examination of lymphocytic infiltration at salivary glands, at least one focus score, Positive antibody titers antiSSA/SSB