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SB-01 clinical trials: The synthetic peptide SB-01, which targets TGF-beta-1 signaling in degenerated discs, is currently in clinical trials
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Since MTX induces oxidative stress by increasing reactive oxygen species in tissues (Reference Jahovic, Cevik and Sehirli38,Reference Moghadam, Tutunchi and Namvaran-Abbas-Abad40,Reference Olayinka, Ore and Adeyemo43) , the effects of various antioxidant substances against MTX-induced oxidative stress have been investigated (Reference Savran, Cicek and Doguc7,Reference Jahovic, Cevik and Sehirli38,Reference Olayinka, Ore and Adeyemo43–Reference Yuksel, Yuksel and Yagmurca45)