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Pre-clinical studies done on C57BL/6J mice using total body irradiation (9 Gy) found that radiation reduced α-diversity of gut microbiota, while urolithin A (UroA), a gut microbial metabolite, helps in alleviating radiation-induced apoptosis in intestinal cells by suppressing P53 signaling pathway (Zhang et al., 2021c

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No significant changes ( 10%) were identified in peptides from ATG13 or ATG101 which suggests that PI containing membranes do not directly or allosterically modulate these proteins of the ULK1 complex (Figure 3A, B)