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The excessive production of GH and associated complications has been studied long before its broader role in human health was discovered

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In the same species, BB increased GH release and inhibits the expression of somatostatin (123, 124), and it has been postulated that the actions of BB in the regulation of GH in these species could be mediated by somatostatin ( Ghrelin Ghrelin was originally reported in 1999 (247), as the first and only known endogenous ligand of the growth hormone secretagogue receptor 1a (GHS–R1a) (248)