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Beyond its direct antioxidant and anti-apoptotic actions, melatonin also supports oocyte-granulosa cell communication by preserving the expression of key oocyte-derived growth factors such as BMP15 and GDF9, which are essential for folliculogenesis and oocyte competence
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It should be noted that the therapeutic concepts discussed herein—including mitochondria-targeted drug delivery, organelle transplantation and genome editing—remain predominantly preclinical, and the translation of these strategies into clinically validated disease-modifying therapies will require rigorous demonstration of safety, efficacy and reproducibility in human studies