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2005, titled “Relationship between cocaine use and mental health problems in a sample of European cocaine powder or crack users.” The findings highlight cocaine’s profound impact on mental health, presenting a wide range of psychiatric symptoms such as agitation, paranoia (affecting 68–84% of users), hallucinations, delusions, and violent behaviors (up to 55%)

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Among them, CCL2, CCR1, CCR2, and CCR5 have achieved good clinical results (125, 126) ( Figure 2 )