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A C18 fatty diacid moiety conjugated via a γ-Glu–2×mini-PEG linker to a specific Lys side chain confers reversible, non-covalent albumin binding—the same albumin-buffering strategy employed by semaglutide—extending the effective half-life from the ~2-minute plasma half-life of native amylin to approximately seven days in preclinical models