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Methods: For this analysis of the multicenter CASPR study, we categorized patients into three groups: (1) those with an identified mechanism (e.g., PFO, device-detected AF within 12 months, ipsilateral 30–50% ulcerated atherosclerosis or carotid web, or grade ⩾4 aortic arch atheroma), (2) those with no identifiable mechanism despite advanced workup (ESUS-AW), and (3) those without advanced workup (ESUS-NAW)
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