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Target Organs of Metals Released from Metal-on-Polyethylene Knee and Hip Arthroplasty Implants: Implications for Tissue Metal Profiles

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The daily legume and whole-grain foundation of the centenarian plate delivered consistent NAD+ precursor inputs through both the Preiss-Handler (niacin) and de novo (tryptophan) pathways, maintaining the substrate availability that both biosynthetic routes require